Invention Grant
- Patent Title: Compositions and methods for inhibiting expression of factor V
- Patent Title (中): 抑制因子V表达的组合物和方法
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Application No.: US14155239Application Date: 2014-01-14
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Publication No.: US09441225B2Publication Date: 2016-09-13
- Inventor: Hans-Peter Vornlocher , John M. Maraganore
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Fenwick & West LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04 ; C12N15/113 ; A61K47/48 ; A61K48/00
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of Factor V, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of Factor V. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of Factor V using the pharmaceutical composition; and methods for inhibiting the expression of Factor V in a cell.
Public/Granted literature
- US20140206747A1 Compositions And Methods For Inhibiting Expression of Factor V Public/Granted day:2014-07-24
Information query
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