Invention Grant
US09441228B2 Post-synthetic chemical modification of RNA at the 2′-position of the ribose ring via “click” chemistry
有权
通过“点击”化学，在核糖环的2'-位上进行RNA的后合成化学修饰
- Patent Title: Post-synthetic chemical modification of RNA at the 2′-position of the ribose ring via “click” chemistry
- Patent Title (中): 通过“点击”化学，在核糖环的2'-位上进行RNA的后合成化学修饰
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Application No.: US14609118Application Date: 2015-01-29
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Publication No.: US09441228B2Publication Date: 2016-09-13
- Inventor: Daniel Zewge , Francis Gosselin
- Applicant: SIRNA THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: Sirna Therapeutics, Inc.
- Current Assignee: Sirna Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C12N15/113 ; C07C217/40 ; C07C217/52 ; C07D207/08 ; C07D207/12 ; C07D209/48 ; C07D211/22 ; C07D211/44 ; C07D211/46 ; C07D295/088 ; C07H21/02
Abstract:
This invention relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having an alkyne functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand. This invention also relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having a triazole functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand.
Public/Granted literature
- US20150211008A1 POST-SYNTHETIC CHEMICAL MODIFICATION OF RNA AT THE 2'-POSITION OF THE RIBOSE RING VIA "CLICK" CHEMISTRY Public/Granted day:2015-07-30
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