In a fuel injection system of an internal combustion engine, having a combustion chamber with at least one intake valve at an intake side and with at least one exhaust valve at an exhaust side of the combustion chamber and a central injection nozzle for injecting fuel into the combustion chamber, the injection nozzle has injection orifices which are designed and oriented in such a way that a first quantity of fuel is injected into the intake side, a second quantity of fuel injected is into the exhaust side, and a third quantity of fuel which is about equal to the first quantity and greater than the second quantity is injected into a boundary area between the intake and the exhaust sides, providing for a low-emission operation of the internal combustion engine.