A method and system for construction and rendering of annotations associated with an electronic image is disclosed. The system comprises a first data repository for storing the electronic image, which has a plurality of pixels, with one or more pixels annotated at a plurality of levels, which contain descriptive characteristics of the pixel, in ascending magnitude, such that the descriptive characteristics at a subsequent level are with reference to descriptive characteristics of one or more pixels surrounding the pixel. The system comprises a second data repository for storing the annotations. An image display module is configured to display the electronic image. A pixel and level identification module is configured to receive pixel and level selection details from a user-interface. An annotation retrieval module is configured to retrieve annotations corresponding to the pixel and level selection from the second repository and renders the retrieved annotations for the electronic image.