A locking regulating device for drawer slide rail, comprising a slide rail component and a drawer, wherein the drawer is fixedly connected with the movable rail on the slide rail component, characterized in that, a locking regulating device fixed on the drawer is also included, the drawer is designed to latch the square hole on the movable rail through the locking regulating device to realize mutual connection; the locking regulating device comprises a locking mechanism and a regulating mechanism; the locking mechanism is composed of a handle and a lock catch through mutual transmission; through the lock catch, the regulating device is self-locked on the movable rail and acts on the handle to complete unlocking of the lock catch; the regulating mechanism is designed to respectively make three-dimensional regulation to the drawer from up/down, left/right and front/back directions. The present utility model realizes locking and three-dimensional regulation through the locking mechanism and the regulating mechanism. The locking mechanism is designed to realize self-locking by locking the movable rail through lock catch and perform unlocking through handle transmission to lock catch, so as to conveniently realize the unlocking and separation between drawer and movable rail. The regulating mechanism is designed to respectively make regulation to the drawer in the up/down, left/right and front/back direction, thus contributes to the coordination between drawer and movable rail and meets the demand of different consumers.