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US09446067B2 Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof 有权
巯基改性的巯基改性生物相容性大分子衍生物和交联材料及其用途

Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof
Abstract:
The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group. The present invention further discloses a disulfide-bond cross-linked biocompatible macromolecule material with a very low degree of cross-linking. The disulfide-bond cross-linked biocompatible macromolecule material not only maintains the initial structure, physiological function and biocompatibility of the biocompatible macromolecule as much as possible, but also effectively prolongs turn over and reduces the solubility of the biocompatible macromolecule in vivo, better meeting the requirements of various clinical applications. The present invention further relates to the application of the disulfide-bond cross-linked biocompatible macromolecule material in the field of medicine and pharmacy.
Abstract(Chinese):

本发明公开了一种巯基改性的生物相容性大分子衍生物，其改性程度较低。 巯基改性的生物相容性高分子衍生物不仅可以尽可能维持初始结构，生理功能和生物相容性，而且可以通过有效的化学交联制备具有低交联度的生物相容性大分子交联材料， 与引入的巯基连接。 本发明还公开了具有非常低的交联度的二硫键交联的生物相容性大分子材料。 二硫键交联生物相容性高分子材料不仅可以保持生物相容性大分子的初始结构，生理功能和生物相容性，而且有效延长生物相容性大分子在体内的溶解度，更好地满足 要求各种临床应用。 本发明还涉及二硫键交联生物相容性大分子材料在医药领域的应用。

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