Invention Grant
- Patent Title: Pharmaceutical composition for preventing and treating complications of diabetes containing a traditional oriental medicine extract or a fraction thereof as an active ingredient
- Patent Title (中): 用于预防和治疗含有传统东方医药提取物或其部分的糖尿病并发症的药物组合物作为活性成分
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Application No.: US13983802Application Date: 2011-03-07
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Publication No.: US09446081B2Publication Date: 2016-09-20
- Inventor: Jin Sook Kim, I , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
- Applicant: Jin Sook Kim, I , Jung Hyun Kim , Young Sook Kim , Chan-Sik Kim , Ohn Soon Kim , Eun Jin Shon , Nam-Hee Yoo , Yun Mi Lee , Dong Ho Jung
- Applicant Address: KR Daejeon
- Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
- Current Assignee: KOREA INSTITUTE OF ORIENTAL MEDICINE
- Current Assignee Address: KR Daejeon
- Agency: Norton Rose Fulbright US LLP
- International Application: PCT/KR2011/000896 WO 20110307
- International Announcement: WO2012/121423 WO 20120913
- Main IPC: A61K36/47
- IPC: A61K36/47 ; A61K36/00 ; A23L1/30 ; A23L1/314 ; A23L1/39 ; A23L2/52 ; A23K1/16 ; A23K1/18
Abstract:
The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetic complications comprising the extract of Homonoia riparia Lour. or the fraction thereof as an active ingredient. More particularly, the extract of Homonoia riparia Lour. or the fractions thereof of the present invention can inhibit the activity of aldose reductase and the generation of the advanced glycation endproducts, the index of diabetic complications, and have powerful activity of inhibiting diabetic complications with brining the anti-cataract, anti-retinopathy, and anti-neuropathy effect, and have the activity of anti-oxidation as well, so that they can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of diabetic complications.
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