One or more free radical scavengers are used as prophylactically or therapeutically effective substances amd microparticles having an average particle size ranging from 5 to 200 μm for the preaparation of a topuical pharmaceutical compostion for the protection or treatment of skin or hair damages caused buy chemotherapeutic treatment. The invention also concerns a method for the protextion or treatmnent of skin or hair damages of a mammal caused by chemotherapy. A kit for the protextion or treatment of hair damages caused by chemotherapeutic treatment consists of a topical composition including microparticles together with the free radical scavengers and a shampoo for an effective hair cleaning and supporting the hair treatment. A kit for the protection or treatment of skin damages caused by chemotherapy consists of a topical composition including microparticles together with free radical scavengers and a cleansing milk for an effective skin cleaning and supporting the skin treatment.