Invention Grant
US09446091B2 Caspofungin or salts thereof with high purity, as well as preparation method and use thereof
有权
卡泊芬净或其盐，其纯度高，以及其制备方法和用途
- Patent Title: Caspofungin or salts thereof with high purity, as well as preparation method and use thereof
- Patent Title (中): 卡泊芬净或其盐，其纯度高，以及其制备方法和用途
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Application No.: US14113296Application Date: 2012-04-20
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Publication No.: US09446091B2Publication Date: 2016-09-20
- Inventor: Bingming He , Ming Li , Zhijun Tang , Xiaoming Ji
- Applicant: Bingming He , Ming Li , Zhijun Tang , Xiaoming Ji
- Applicant Address: CN Shanghai
- Assignee: Shanghai Techwell Biopharmaceutical Co., Ltd.
- Current Assignee: Shanghai Techwell Biopharmaceutical Co., Ltd.
- Current Assignee Address: CN Shanghai
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: CN201110101870 20110422
- International Application: PCT/CN2012/074420 WO 20120420
- International Announcement: WO2012/142959 WO 20121026
- Main IPC: C07K7/56
- IPC: C07K7/56 ; A61K38/12 ; A61K38/00 ; C07K7/54 ; A61K31/19
Abstract:
Disclosed are a high purity of caspofungin or salts thereof, and a preparation method thereof, and use thereof. Disclosed are a caspofungin or salts thereof with low solvent residue and hyposaline, and a preparation process comprising: dissolving a crude product of caspofungin or salts thereof into a system of water and acetic acid, then mixing with a first organic solvent ethyl alcohol, subsequently mixing with a second organic solvent ethyl acetate, then being subject to filtration and drying together with water, to obtain caspofungin or salts thereof with high stability, low solvent residue and hyposaline.
Public/Granted literature
- US20140128315A1 CASPOFUNGIN OR SALTS THEREOF WITH HIGH PURITY, AS WELL AS PREPARATION METHOD AND USE THEREOF Public/Granted day:2014-05-08
Information query
