Invention Grant
US09446096B2 Glypican-4 based compositions and methods for treating and diagnosing insulin resistance
有权
基于磷脂酰基胰蛋白聚糖-4的组合物和治疗和诊断胰岛素抵抗的方法
- Patent Title: Glypican-4 based compositions and methods for treating and diagnosing insulin resistance
- Patent Title (中): 基于磷脂酰基胰蛋白聚糖-4的组合物和治疗和诊断胰岛素抵抗的方法
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Application No.: US14369095Application Date: 2012-12-31
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Publication No.: US09446096B2Publication Date: 2016-09-20
- Inventor: Siegfried Ussar , C. Ronald Kahn
- Applicant: Joslin Diabetes Center, Inc.
- Applicant Address: US MA Boston
- Assignee: Joslin Diabetes Center, Inc.
- Current Assignee: Joslin Diabetes Center, Inc.
- Current Assignee Address: US MA Boston
- Agency: Pierce Atwood LLP
- Agent Kevin M. Farrell; David J. Wilson
- International Application: PCT/US2012/072310 WO 20121231
- International Announcement: WO2013/102209 WO 20130704
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/00 ; A61P5/50 ; G01N33/68
Abstract:
Provided herein are methods for increasing insulin sensitivity in a subject. A method may comprise administering to a subject in need of increased insulin sensitivity a therapeutically effective amount of a glypican-4 agent. Also provided herein are methods for determining whether a subject is or is likely to become insulin resistant. A method may comprise determining the level of glypican-4 in a subject, wherein an elevated level of glypican-4 indicates that a subject is or is likely to become insulin resistant.
Public/Granted literature
- US20140364363A1 GLYPICAN-4 BASED COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING INSULIN RESISTANCE Public/Granted day:2014-12-11
Information query
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