Invention Grant
US09446132B2 Diether based biodegradable cationic lipids for siRNA delivery
有权
基于Diether的生物降解阳离子脂质用于siRNA递送
- Patent Title: Diether based biodegradable cationic lipids for siRNA delivery
- Patent Title (中): 基于Diether的生物降解阳离子脂质用于siRNA递送
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Application No.: US14388597Application Date: 2013-03-25
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Publication No.: US09446132B2Publication Date: 2016-09-20
- Inventor: Matthew G. Stanton , Brian W. Budzik , Steven L. Colletti
- Applicant: SIRNA THERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: Sima Therapeutics, Inc.
- Current Assignee: Sima Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- International Application: PCT/US2013/033641 WO 20130325
- International Announcement: WO2013/148541 WO 20131003
- Main IPC: A61K47/14
- IPC: A61K47/14 ; A61K47/18 ; A61K9/127 ; A61K47/10 ; A61K47/24 ; A61K47/28 ; C07C217/40 ; C12N15/113 ; C07C217/28 ; C12N15/88 ; A61K9/51
Abstract:
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Public/Granted literature
- US20150057373A1 DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY Public/Granted day:2015-02-26
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