Invention Grant
- Patent Title: Thioaryl derivatives as GPR120 agonists
- Patent Title (中): 硫代芳基衍生物作为GPR120激动剂
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Application No.: US14440495Application Date: 2013-11-05
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Publication No.: US09447044B2Publication Date: 2016-09-20
- Inventor: Young Kwan Kim , Myoung Yeol Kim , Sang Yun Park , Ok Ku Park , Vasily Artemov , Sang Dae Lee , Hyun Woo Joo , Eun Sil Choi
- Applicant: LG LIFE SCIENCES LTD.
- Applicant Address: KR Seoul
- Assignee: LG LIFE SCIENCES LTD.
- Current Assignee: LG LIFE SCIENCES LTD.
- Current Assignee Address: KR Seoul
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: KR10-2012-0124502 20121105
- International Application: PCT/KR2013/009928 WO 20131105
- International Announcement: WO2014/069963 WO 20140508
- Main IPC: C07D213/70
- IPC: C07D213/70 ; A61K31/44 ; C07D213/80 ; C07D241/18
Abstract:
The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.
Public/Granted literature
- US20150291527A1 THIOARYL DERIVATIVES AS GPR120 AGONISTS Public/Granted day:2015-10-15
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