Invention Grant
US09447055B1 α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
有权
羟基噻唑烷羧酰胺衍生物的α-氨基酯和盐形式，其晶体多晶型物
- Patent Title: α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
- Patent Title (中): 羟基噻唑烷羧酰胺衍生物的α-氨基酯和盐形式，其晶体多晶型物
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Application No.: US14987586Application Date: 2016-01-04
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Publication No.: US09447055B1Publication Date: 2016-09-20
- Inventor: Patrick Naxos Page , Matthias Schwarz , Catherine Jorand-Lebrun , Anna Quattropani , Vincent Pomel
- Applicant: Merck Serono S.A.
- Applicant Address: CH Coinsins
- Assignee: Merck Serono S.A.
- Current Assignee: Merck Serono S.A.
- Current Assignee Address: CH Coinsins
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- Main IPC: C07D277/06
- IPC: C07D277/06
Abstract:
The invention provides α-amino esters of a hydroxypropylthiazolidine carboxamide derivative, (2S)-3-([1,1′-biphenyl]-4-ylsulfonyl)-N-[(1S)-3-hydroxy-1-phenylpropyl]-1,3-thiazolidine-2-carboxamide, as well as salts and crystal polymorphs thereof, that can be used to inhibit prostaglandin F receptor. The invention further encompasses methods of treating disorders such as pre-term labor at the early gestational stage by the administration of these substances to a patient in need of treatment.
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