Invention Grant
US09447062B2 Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E
有权
称为科拉霉素E的Manumycin型代谢物，其抑制半胱天冬酶1和产生白介素，菌株产生科拉霉素E和生产科拉霉素E的方法
- Patent Title: Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E
- Patent Title (中): 称为科拉霉素E的Manumycin型代谢物，其抑制半胱天冬酶1和产生白介素，菌株产生科拉霉素E和生产科拉霉素E的方法
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Application No.: US14570862Application Date: 2014-12-15
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Publication No.: US09447062B2Publication Date: 2016-09-20
- Inventor: Miroslav Petricek , Katerina Petrickova , Stanislav Pospisil , Marek Kuzma , Alica Chronakova , Vaclav Kristufek , Ilja Striz
- Applicant: BIOLOGY CENTRE AS CR, v. v. i. , INSTITUTE OF MICROBIOLOGY AS CR, v. v. i. , INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
- Applicant Address: CZ Ceske Budejovice CZ Prague CZ Prague
- Assignee: BIOLOGY CENTRE AS CR, V.V.I.,INSTITUTE OF MICROBIOLOGYH AS CR, V.V.I.,INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
- Current Assignee: BIOLOGY CENTRE AS CR, V.V.I.,INSTITUTE OF MICROBIOLOGYH AS CR, V.V.I.,INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
- Current Assignee Address: CZ Ceske Budejovice CZ Prague CZ Prague
- Agency: Notaro, Michalos & Zaccaria P.C.
- Main IPC: C07D303/00
- IPC: C07D303/00 ; C07D303/46 ; C12P13/02
Abstract:
A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1β release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
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