Invention Grant
US09447099B2 Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
有权
制备5- [2- [7-（三氟甲基）-5- [4-（三氟甲基）苯基]吡唑并[1,5-a]嘧啶-3-基[乙炔基] -2-吡啶胺
![Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine](/docs/US/2016-09-20/US09447099B2/abs.jpg.600x600.jpg)
- Patent Title: Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
- Patent Title (中): 制备5- [2- [7-（三氟甲基）-5- [4-（三氟甲基）苯基]吡唑并[1,5-a]嘧啶-3-基[乙炔基] -2-吡啶胺
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Application No.: US13628069Application Date: 2012-09-27
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Publication No.: US09447099B2Publication Date: 2016-09-20
- Inventor: Stephan Bachmann , Daniel Bailey , Jodie Brice , Miall Cedilote , Zhiming Dong , Stefan Hildbrand , Doreen Miller , Paul Spurr , Amit Srivastava , Juergen Wichmann , Thomas Woltering , Jason Yang , Pingsheng Zhang
- Applicant: Roche Carolina Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Tamara A. Kale
- Main IPC: C07D213/73
- IPC: C07D213/73 ; C07D487/04
![Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine](/abs-image/US/2016/09/20/US09447099B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities.
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