Invention Grant
- Patent Title: Synthetic lung surfactant and use thereof
-
Application No.: US14030719Application Date: 2013-09-18
-
Publication No.: US09447127B2Publication Date: 2016-09-20
- Inventor: Robert H. Notter , Zhengdong Wang , Adrian L. Schwan , Zhongyi Wang , Jason A. Davy , Alan J Waring , Frans Walther , Larry M. Gordon
- Applicant: University of Rochester , University of Guelph , The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Applicant Address: US NY Rochester US CA Torrance CA Guelph, Ontario
- Assignee: University of Rochester,The Los Angeles Biomedical Research Institute of Harbor-UCLA Medical Center,University of Guelph
- Current Assignee: University of Rochester,The Los Angeles Biomedical Research Institute of Harbor-UCLA Medical Center,University of Guelph
- Current Assignee Address: US NY Rochester US CA Torrance CA Guelph, Ontario
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07F9/09 ; A61K9/00 ; C07F9/40 ; C07K14/00 ; C07K14/785
Abstract:
The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
Public/Granted literature
- US20140044775A1 SYNTHETIC LUNG SURFACTANT AND USE THEREOF Public/Granted day:2014-02-13
Information query
IPC分类:
