Invention Grant
- Patent Title: Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
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Application No.: US13886104Application Date: 2013-05-02
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Publication No.: US09447181B2Publication Date: 2016-09-20
- Inventor: John Powell , Duncan Casson , Mark Maginn , Wei Liu , Sandeep Dutta , Andrea Best , Jerry A. Hall
- Applicant: AbbVie Research B.V.
- Agency: McAndrews, Held & Malloy
- Main IPC: C07K16/22
- IPC: C07K16/22 ; A61K39/395 ; A61K39/00
Abstract:
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Public/Granted literature
- US20130295112A1 Antibodies Against Nerve Growth Factor (NGF) With Enhanced In Vivo Stability Public/Granted day:2013-11-07
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