Invention Grant
US09447389B2 Modified polymerases for improved incorporation of nucleotide analogues
有权
用于改善核苷酸类似物掺入的修饰聚合酶
- Patent Title: Modified polymerases for improved incorporation of nucleotide analogues
- Patent Title (中): 用于改善核苷酸类似物掺入的修饰聚合酶
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Application No.: US14476387Application Date: 2014-09-03
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Publication No.: US09447389B2Publication Date: 2016-09-20
- Inventor: Geoffrey Paul Smith , David Mark Dunstan Bailey , Raquel Maria Sanches-Kuiper , Harold Swerdlow , David James Earnshaw
- Applicant: Illumina Cambridge Limited
- Applicant Address: GB Nr Saffron Walden
- Assignee: Illumina Cambridge Limited
- Current Assignee: Illumina Cambridge Limited
- Current Assignee Address: GB Nr Saffron Walden
- Agency: Mueting, Raasch & Gebhardt, P.A.
- Priority: GB0321306.3 20030911
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
Public/Granted literature
- US20150024463A1 MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES Public/Granted day:2015-01-22
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