- Patent Title: Aldehyde tags, uses thereof in site-specific protein modification
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Application No.: US14464528Application Date: 2014-08-20
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Publication No.: US09447390B2Publication Date: 2016-09-20
- Inventor: Isaac S. Carrico , Brian L. Carlson , Peng Wu , Carolyn Bertozzi
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol Francis; Rudy Ng
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C07K1/00 ; C07K1/13 ; C07K1/107 ; C07K14/00 ; C07K16/46 ; C12P21/00 ; C07K14/35 ; C07K14/565 ; C07K16/00 ; C12N9/96
Abstract:
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
Public/Granted literature
- US20150072398A1 Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification Public/Granted day:2015-03-12
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