Invention Grant
US09447394B2 Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
有权
使用包含myotubularin 1（MTM1）多肽的嵌合多肽治疗肌管肌病的方法和组合物
- Patent Title: Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides
- Patent Title (中): 使用包含myotubularin 1（MTM1）多肽的嵌合多肽治疗肌管肌病的方法和组合物
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Application No.: US14485524Application Date: 2014-09-12
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Publication No.: US09447394B2Publication Date: 2016-09-20
- Inventor: Dustin D. Armstrong
- Applicant: Valerion Therapeutics, LLC
- Applicant Address: US MA Concord
- Assignee: Valerion Therapeutics, LLC
- Current Assignee: Valerion Therapeutics, LLC
- Current Assignee Address: US MA Concord
- Agency: Ropes & Gray LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C12N9/00 ; C12N9/16 ; A61K47/48 ; C07K16/44 ; A61K38/00 ; A61K39/00
Abstract:
The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalizing moiety, wherein, the moiety can be an antibody, and is preferably monoclonal antibody 3E10, a functional variant or a fragment thereof. One aspect of the present invention provides compositions comprising these chimeric polypeptides together with a pharmaceutically acceptable carrier, and optionally, a further therapeutic agent. Another aspect of the present invention provides methods of treating Myotubular Myopathy comprising administering the polypeptides or compositions comprising the polypeptides to a subject in need.
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