Invention Grant
- Patent Title: Pro- and anti-angiogenic treatments
- Patent Title (中): 抗血管生成治疗
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Application No.: US12530596Application Date: 2008-03-10
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Publication No.: US09447418B2Publication Date: 2016-09-20
- Inventor: David Bates , Steven James Harper , Dawid Grzegorz Nowak
- Applicant: David Bates , Steven James Harper , Dawid Grzegorz Nowak
- Applicant Address: GB Bristol
- Assignee: UNIVERSITY OF BRISTOL
- Current Assignee: UNIVERSITY OF BRISTOL
- Current Assignee Address: GB Bristol
- Agency: Harness, Dickey & Pierce, P.L.C.
- Priority: GB0704678.2 20070309
- International Application: PCT/GB2008/000824 WO 20080310
- International Announcement: WO2008/110777 WO 20080918
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C12N15/113 ; A61K31/535
Abstract:
The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
Public/Granted literature
- US20100210527A1 PRO- AND ANTI-ANGIOGENIC TREATMENTS Public/Granted day:2010-08-19
Information query
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