Invention Grant
US09447443B2 Method for producing 3-acetylamino-4-hydroxybenzoic acid 有权
3-乙酰氨基-4-羟基苯甲酸的制备方法

Method for producing 3-acetylamino-4-hydroxybenzoic acid
Abstract:
The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.
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