A method and an apparatus to reproduce a multi-channel audio signal, in which mixing of a center channel signal is performed with a center channel signal in a home theater system. The method of reproducing a multi-channel audio signal includes calculating a delay value of a center channel signal according to location relationships of a listener, a center channel speaker and other channel speakers, regulating a time delay of the center channel signal according to the calculated delay value, and mixing the time-delay regulated center channel signal with other channel signals.