An endoscopic diagnosis system includes a first narrowband light source for emitting first narrowband light having a given wavelength range, a second narrowband light source for emitting second narrowband light having a wavelength range different from that of the first narrowband light, a first image sensor for receiving reflected light of the first narrowband light illuminating a subject from the subject to acquire a narrowband light image in a narrowband light observation mode, a second image sensor for receiving first autofluorescence emitted from the subject as the first narrowband light illuminates the subject to acquire a first autofluorescence image in a first autofluorescence observation mode and receiving second autofluorescence emitted from the subject as the second narrowband light illuminates the subject to acquire a second autofluorescence image in a second autofluorescence observation mode.