Invention Grant
US09456995B2 Methods for inhibition of BNIP3 and prevention and treatment of ischemia reperfusion injury by tetra-O-methyl nordihydroguaiaretic acid
有权
抑制BNIP3和预防和治疗四-O-甲基诺二氢愈创木酸的缺血再灌注损伤的方法
- Patent Title: Methods for inhibition of BNIP3 and prevention and treatment of ischemia reperfusion injury by tetra-O-methyl nordihydroguaiaretic acid
- Patent Title (中): 抑制BNIP3和预防和治疗四-O-甲基诺二氢愈创木酸的缺血再灌注损伤的方法
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Application No.: US14415163Application Date: 2013-07-18
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Publication No.: US09456995B2Publication Date: 2016-10-04
- Inventor: Ru Chih Huang , Kotohiko Kimura
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: John Hopkins Technology Transfer
- International Application: PCT/US2013/051074 WO 20130718
- International Announcement: WO2014/015136 WO 20140123
- Main IPC: A61K31/085
- IPC: A61K31/085 ; A61K31/09
Abstract:
Provided herein are methods for prevention and treatment of ischemia-reperfusion (IR) injury in the cardiac myocytes of a subject, by administration to the subject, a compound of formula I, or a salt, solvate, or stereoisomer thereof, in a sufficient amount either prior to, or during and/or after an ischemic event to mitigate or prevent IR injury to the cardiac tissue. Pharmaceutical compositions including the compound of formula I, or a salt, solvate, or stereoisomer thereof, and/or at least one additional therapeutic agent, are also provided.
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