Invention Grant
US09457098B2 Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
有权
不对称双官能甲硅烷基单体及其颗粒作为药物，化学和生物制剂的前药和递送载体
- Patent Title: Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
- Patent Title (中): 不对称双官能甲硅烷基单体及其颗粒作为药物，化学和生物制剂的前药和递送载体
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Application No.: US14482624Application Date: 2014-09-10
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Publication No.: US09457098B2Publication Date: 2016-10-04
- Inventor: Joseph M. DeSimone , Mathew Finniss , Mary Napier , Ashish Pandya , Matthew Parrott
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Alston & Bird LLP
- Main IPC: C07K19/00
- IPC: C07K19/00 ; A61K38/00 ; A61K47/48 ; B82Y5/00 ; C07F7/08 ; C07F7/18 ; C07H23/00
Abstract:
Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.
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