An airport baggage handling system is described for transferring baggage between airport passenger stations and aircraft loading zones. The airport baggage handling system includes in-line screening devices including at least one high resolution or high risk screening device and at least one low resolution or low risk screening device. Each piece of checked baggage is provided with a tag including, inter alia, information regarding the security status of the piece of baggage. A computer control system for controlling operation of the baggage handling system uses the information regarding the security status of the piece of baggage to selectively route the piece of baggage through one of the high and low risk scanning devices. In one embodiment, the security status of the baggage is derived from the security status of the passenger associated with the baggage.