Invention Grant
- Patent Title: α-Substituted glycinamide derivative
- Patent Title (中): α-取代的甘氨酰胺衍生物
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Application No.: US14889475Application Date: 2014-05-07
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Publication No.: US09458092B2Publication Date: 2016-10-04
- Inventor: Hideaki Hirasawa , Naohiro Kawamura , Junichi Kobayashi
- Applicant: KISSEI PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Matsumoto-shi
- Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Matsumoto-shi
- Agency: Sughrue Mion, PLLC
- Priority: JP2013-098835 20130508
- International Application: PCT/JP2014/062218 WO 20140507
- International Announcement: WO2014/181788 WO 20141113
- Main IPC: A61K31/167
- IPC: A61K31/167 ; C07C233/81 ; C07C255/60 ; C07D213/81 ; C07D213/82 ; C07D213/84 ; C07C271/22 ; C07D215/54 ; C07D217/26 ; C07D221/04 ; C07D317/62 ; C07D231/14 ; C07D333/38 ; C07D333/70 ; C07D233/90 ; C07D237/08 ; C07D237/24 ; C07D239/26 ; C07D239/28 ; C07D405/12 ; C07D409/12 ; C07D241/12 ; C07D241/24 ; C07D417/12 ; C07D471/04 ; C07D261/18 ; C07D487/04 ; C07D263/34 ; C07C237/22 ; C07C237/36 ; C07D271/08 ; C07D275/02 ; C07D277/20 ; C07D277/30 ; C07D277/56 ; C07D213/56 ; C07D307/78 ; C07D307/82

Abstract:
The present invention is to provide a novel α-substituted glycinamide derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof.The present invention provides a compound represented by the general formula (I), which has TRPM8 inhibitory effects: [wherein A1 represents a C6-10 aryl and the like, A2 represents a C6-10 aryl and the like, X represents CH and the like, Y represents —CR1R2— and the like, R1 and R2 independently represent a hydrogen atom and the like, R3 and R4 independently represent a halogen atom and the like, n is 1 or 2], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons.
Public/Granted literature
- US20160115119A1 alpha-SUBSTITUTED GLYCINAMIDE DERIVATIVE Public/Granted day:2016-04-28
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