Invention Grant
- Patent Title: Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor RORγ
- Patent Title (中): 羧酰胺或磺酰胺取代的含氮5元杂环作为孤儿核受体RORγ的调节剂
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Application No.: US14419468Application Date: 2013-05-29
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Publication No.: US09458104B2Publication Date: 2016-10-04
- Inventor: Christian Gege , Olaf Kinzel , Christoph Steeneck , Gerald Kleymann , Thomas Hoffmann
- Applicant: PHENEX PHARMACEUTICALS AG
- Applicant Address: DE Ludwigshafen
- Assignee: Phenex Pharmaceuticals AG
- Current Assignee: Phenex Pharmaceuticals AG
- Current Assignee Address: DE Ludwigshafen
- Agency: Seed IP Law Group PLLC
- Priority: EP12005789 20120809
- International Application: PCT/EP2013/001594 WO 20130529
- International Announcement: WO2014/023367 WO 20140213
- Main IPC: C07D231/14
- IPC: C07D231/14 ; C07D207/34 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D401/06 ; C07D491/107 ; C07D495/10 ; C07D413/12 ; C07D401/04 ; C07D405/04 ; C07D249/10
Abstract:
The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
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