Invention Grant
- Patent Title: Inhibitors of Bruton's tyrosine kinase
- Patent Title (中): Bruton酪氨酸激酶抑制剂
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Application No.: US14441711Application Date: 2013-11-13
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Publication No.: US09458105B2Publication Date: 2016-10-04
- Inventor: Romyr Dominique , Francisco Javier Lopez-Tapia , Eric Mertz , Sung-Sau So
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- International Application: PCT/EP2013/073667 WO 20131113
- International Announcement: WO2014/076104 WO 20140522
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/10 ; C07D213/643 ; C07D401/12 ; C07D495/04 ; C07D211/82

Abstract:
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
Public/Granted literature
- US20150291525A1 INHIBITORS OF BRUTON'S TYROSINE KINASE Public/Granted day:2015-10-15
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