Invention Grant
US09458112B2 Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
有权
用于抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物
- Patent Title: Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
- Patent Title (中): 用于抑制ABL1，ABL2和BCR-ABL1活性的化合物和组合物
-
Application No.: US15060723Application Date: 2016-03-04
-
Publication No.: US09458112B2Publication Date: 2016-10-04
- Inventor: Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Jones , Paul William Manley , Andreas Marzinzik , Saliha Moussaoui , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer
- Applicant: Pascal Furet , Robert Martin Grotzfeld , Wolfgang Jahnke , Darryl Jones , Paul William Manley , Andreas Marzinzik , Saliha Moussaoui , Xavier Francois Andre Pelle , Bahaa Salem , Joseph Schoepfer
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Main IPC: C07D239/26
- IPC: C07D239/26 ; C07D401/04 ; A61K31/505 ; C07D239/34 ; A61K31/506 ; C07D241/20 ; A61K31/4965 ; C07D241/12 ; C07D333/38 ; A61K31/381 ; C07D409/06 ; A61K31/4025 ; C07D233/56 ; A61K31/4164 ; C07D277/30 ; A61K31/426 ; C07D231/12 ; A61K31/415 ; C07D405/14 ; A61K31/4439 ; C07D403/04 ; C07D317/60 ; A61K31/36 ; C07D333/22 ; A61K31/5377 ; A61K45/06
Abstract:
The present invention relates to compounds of formula I: in which Y, Y1, Y4, Y5, Y6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
Public/Granted literature
- US20160185733A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 Public/Granted day:2016-06-30
Information query
