Invention Grant
- Patent Title: Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
- Patent Title (中): 异噻唑衍生物作为PIM激酶抑制剂及其药物制备方法和用途
-
Application No.: US14746720Application Date: 2015-06-22
-
Publication No.: US09458151B2Publication Date: 2016-10-04
- Inventor: Yu Ge
- Applicant: Jikai Biosciences, Inc.
- Applicant Address: CN Shanghai
- Assignee: Jikai Biosciences, Inc.
- Current Assignee: Jikai Biosciences, Inc.
- Current Assignee Address: CN Shanghai
- Agency: Mei & Mark LLP
- Agent Manni Li
- Priority: CN201110229731 20110811; CN201210271738 20120801
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D417/12 ; C07D417/14 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D403/14 ; C07D451/02 ; C07D451/06 ; C07D453/02 ; C07D471/08 ; C07D487/08 ; C07D403/02 ; C07D413/12
Abstract:
PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.
Public/Granted literature
Information query
IPC分类:
