Invention Grant
- Patent Title: DOT1L inhibitors
- Patent Title (中): DOT1L抑制剂
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Application No.: US14838142Application Date: 2015-08-27
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Publication No.: US09458165B2Publication Date: 2016-10-04
- Inventor: James E. Bradner , Jun Qi , Alexander Federation
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04
Abstract:
Provided herein are inhibitors of DOT1L of formula (I) useful for treating diseases or disorders associated with DOT1L: in which R1 is defined in the specification. An exemplary DOT1L inhibitor provided herein exhibits a biological half-life of 12.6 h. Methods for treating diseases associated with DOT1L are also provided.
Public/Granted literature
- US20160060269A1 DOT1L Inhibitors Public/Granted day:2016-03-03
Information query
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