Invention Grant
- Patent Title: Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
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Application No.: US14719824Application Date: 2015-05-22
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Publication No.: US09458167B2Publication Date: 2016-10-04
- Inventor: Aleem Gangjee
- Applicant: Duquesne University of the Holy Spirit
- Applicant Address: US PA Pittsburgh
- Assignee: Duquesne University of the Holy Spirit
- Current Assignee: Duquesne University of the Holy Spirit
- Current Assignee Address: US PA Pittsburgh
- Agency: Buchanan Ingersoll & Rooney PC
- Agent Craig G. Cochenour
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D491/048 ; C07D495/04
Abstract:
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
Public/Granted literature
- US20150252053A1 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof Public/Granted day:2015-09-10
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