Invention Grant
US09458174B2 Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof
有权
线粒体电子传递链复合物（III）的活性抑制剂及其用途
- Patent Title: Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof
- Patent Title (中): 线粒体电子传递链复合物（III）的活性抑制剂及其用途
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Application No.: US14401685Application Date: 2013-05-23
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Publication No.: US09458174B2Publication Date: 2016-10-04
- Inventor: Virginie Clement-Schatlo , Thomas Fessard , Damien Barbaras , Joana Matos , Erick Carreira
- Applicant: STEMERGIE BIOTECHNOLOGY SA
- Applicant Address: CH Geneva
- Assignee: Stemergie Biotechnology SA
- Current Assignee: Stemergie Biotechnology SA
- Current Assignee Address: CH Geneva
- Agency: Harness, Dickey and Pierce, P.L.C.
- Priority: CH0715/12 20120523
- International Application: PCT/EP2013/060670 WO 20130523
- International Announcement: WO2013/174974 WO 20131128
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D495/10 ; C07D213/81 ; C07D215/28 ; C07C275/42 ; C07C39/30 ; C07D231/56 ; C07C311/08 ; C07D235/26 ; C07D405/12 ; C07C215/50 ; C07D249/06 ; C07C233/25 ; C07D263/32 ; C07D263/34 ; C07D487/10 ; C07C237/38 ; C07C237/42 ; C07C251/48 ; C07D209/42 ; C07D305/06 ; C07C49/825 ; C07D403/12 ; C07D223/28 ; C07D235/18 ; C07C233/33 ; C07D261/08 ; C07C235/60 ; C07C235/62 ; C07D263/57 ; C07D491/107 ; C07C237/40 ; C07C237/44 ; C07D277/56 ; C07D513/10 ; C07D305/08 ; A01N31/08 ; A01N33/10 ; A01N35/04 ; A01N37/24 ; A01N37/40 ; A01N37/44 ; A01N37/46 ; A01N37/50 ; A01N43/20 ; A01N43/38 ; A01N43/40 ; A01N43/42 ; A01N43/46 ; A01N43/52 ; A01N43/56 ; A01N43/60 ; A01N43/647 ; A01N43/76 ; A01N43/78 ; A01N43/80 ; A01N43/90 ; A01N47/30 ; C07C39/24 ; C07C43/178 ; C07C49/245 ; A61K31/137 ; A61K31/167 ; A61K31/17 ; A61K31/18 ; A61K31/397 ; A61K31/421 ; A61K31/44 ; A61K31/47 ; A61K31/55 ; A61K45/06 ; C07D223/24
Abstract:
The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumor-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.
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