Invention Grant
- Patent Title: Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative
- Patent Title (中): 四氢咪唑并(1,5-D)[1,4]氧氮杂衍生物
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Application No.: US14190356Application Date: 2014-02-26
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Publication No.: US09458176B2Publication Date: 2016-10-04
- Inventor: Mamoru Takaishi , Nobuhiro Sato , Tomoyuki Shibuguchi , Takafumi Motoki , Yoshinori Takahashi , Takeo Sasaki , Alan Braunton
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/553
- IPC: A61K31/553 ; C07D498/04
![Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative](/abs-image/US/2016/10/04/US09458176B2/abs.jpg.150x150.jpg)
Abstract:
A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving the mGluR2, such as Alzheimer's disease: wherein R is a hydrogen atom, a C1-6 alkyl group or the like, R1 is a C1-6 alkyl group, a C1-6 alkoxy group or the like, R2 is a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group or the like, R3 is a hydrogen atom, a C1-6 alkyl group or the like, and R4 is a C1-6 alkyl group or the like.
Public/Granted literature
- US20140243316A1 Tetrahydroimidazo(1,5-D)[1,4]Oxazepine Derivative Public/Granted day:2014-08-28
Information query
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