Invention Grant
- Patent Title: Ligation of stapled polypeptides
- Patent Title (中): 结扎多肽
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Application No.: US14748287Application Date: 2015-06-24
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Publication No.: US09458189B2Publication Date: 2016-10-04
- Inventor: Gregory L. Verdine , Eileen Jeanne Kennedy
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07K1/107
- IPC: C07K1/107 ; C07K14/47 ; C07K14/54 ; A61K38/17 ; A61K38/20 ; A61K38/00
Abstract:
The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.
Public/Granted literature
- US20150376227A1 LIGATION OF STAPLED POLYPEPTIDES Public/Granted day:2015-12-31
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