Invention Grant
- Patent Title: Modified DNA-binding proteins and uses thereof
- Patent Title (中): 修饰的DNA结合蛋白及其用途
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Application No.: US13679684Application Date: 2012-11-16
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Publication No.: US09458205B2Publication Date: 2016-10-04
- Inventor: Philip D. Gregory , Jeffrey C Miller , David Paschon , Edward J. Rebar , Siyuan Tan , Fyodor Urnov , Lei Zhang
- Applicant: Sangamo BioSciences, Inc.
- Applicant Address: US CA Richmond
- Assignee: Sangamo BioSciences, Inc.
- Current Assignee: Sangamo BioSciences, Inc.
- Current Assignee Address: US CA Richmond
- Agency: Pasternak Patent Law
- Agent Susan Abrahamson
- Main IPC: C07K14/195
- IPC: C07K14/195 ; C12N15/90 ; C12N5/071 ; C12N9/10 ; C12N15/63 ; C12N1/16 ; C12N9/22 ; C12N5/04 ; C12P19/34
Abstract:
Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
Public/Granted literature
- US20130196373A1 MODIFIED DNA-BINDING PROTEINS AND USES THEREOF Public/Granted day:2013-08-01
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