Invention Grant
- Patent Title: Nucleic acid encoding chimeric IL-1 receptor type I antagonists
- Patent Title (中): 编码嵌合IL-1受体I型拮抗剂的核酸
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Application No.: US14460563Application Date: 2014-08-15
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Publication No.: US09458216B2Publication Date: 2016-10-04
- Inventor: Thomas M. Barnes , Jinzhao Hou , Bracken M. King
- Applicant: ELEVEN BIOTHERAPEUTICS, INC.
- Applicant Address: US MA Cambridge
- Assignee: ELEVEN BIOTHERAPEUTICS, INC.
- Current Assignee: ELEVEN BIOTHERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Main IPC: C12N15/12
- IPC: C12N15/12 ; C07K14/545 ; A61K38/00

Abstract:
Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.
Public/Granted literature
- US20150087818A1 CHIMERIC IL-1 RECEPTOR TYPE I AGONISTS AND ANTAGONISTS Public/Granted day:2015-03-26
Information query
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