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US09458216B2 Nucleic acid encoding chimeric IL-1 receptor type I antagonists 有权
编码嵌合IL-1受体I型拮抗剂的核酸

Nucleic acid encoding chimeric IL-1 receptor type I antagonists
Abstract:
Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.
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