Invention Grant
US09458223B2 Von willebrand factor variants having improved factor VIII binding affinity
有权
具有改善的因子VIII结合亲和力的冯维勒布兰德因子变体
- Patent Title: Von willebrand factor variants having improved factor VIII binding affinity
- Patent Title (中): 具有改善的因子VIII结合亲和力的冯维勒布兰德因子变体
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Application No.: US14378446Application Date: 2013-02-14
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Publication No.: US09458223B2Publication Date: 2016-10-04
- Inventor: Stefan Schulte , Thomas Weimer , Kay Hofmann
- Applicant: CSL BEHRING GMBH
- Applicant Address: DE Marburg
- Assignee: CSL BEHRING GMBH
- Current Assignee: CSL BEHRING GMBH
- Current Assignee Address: DE Marburg
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: EP12155509 20120215
- International Application: PCT/EP2013/052948 WO 20130214
- International Announcement: WO2013/120939 WO 20130822
- Main IPC: C07K14/755
- IPC: C07K14/755 ; A61K38/00
Abstract:
The present invention relates to a polypeptide comprising a modified von Willebrand Factor (VWF) having a higher Factor VIII binding affinity than non-modified VWF, its pharmaceutical use and method of its preparation.
Public/Granted literature
- US20140357564A1 Von Willebrand Factor Variants Having Improved Factor VIII Binding Affinity Public/Granted day:2014-12-04
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