Invention Grant
US09458428B2 Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
有权
用于从多能细胞快速产生视网膜色素上皮细胞的方法和组合物
- Patent Title: Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
- Patent Title (中): 用于从多能细胞快速产生视网膜色素上皮细胞的方法和组合物
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Application No.: US14405730Application Date: 2013-06-05
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Publication No.: US09458428B2Publication Date: 2016-10-04
- Inventor: Dennis Clegg , David Buchholz , Roxanne Croze , Britney Pennington , Peter Coffey , Lyndsay Leach
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Mountain IP
- International Application: PCT/US2013/044325 WO 20130605
- International Announcement: WO2013/184809 WO 20131212
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/071 ; C12N5/079
Abstract:
The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell culture medium supplements, medium formulations, and methods of using such medium supplements and formulations, in order to effect the rapid differentiation of pluripotent cells into retinal pigmented epithelial cells with very high yields. The invention further includes cell culture media formulations for the efficient maintenance, propagation, and maturation of cultured retinal pigmented epithelial cells.
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