Invention Grant
US09458437B2 Neuroprotective peptides that inhibit interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (zD17) and c-jun N-terminal kinase (JNK)
有权
抑制与含有17（zD17）和c-jun N-末端激酶（JNK）的棕榈酰酰基转移酶锌指DHHC型相互作用的神经保护肽
- Patent Title: Neuroprotective peptides that inhibit interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (zD17) and c-jun N-terminal kinase (JNK)
- Patent Title (中): 抑制与含有17（zD17）和c-jun N-末端激酶（JNK）的棕榈酰酰基转移酶锌指DHHC型相互作用的神经保护肽
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Application No.: US14232268Application Date: 2012-07-12
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Publication No.: US09458437B2Publication Date: 2016-10-04
- Inventor: Max S. Cynader , Guang Yang
- Applicant: Max S. Cynader , Guang Yang
- Applicant Address: CA Vancouver, British Columbia
- Assignee: The University of British Columbia
- Current Assignee: The University of British Columbia
- Current Assignee Address: CA Vancouver, British Columbia
- Agency: Gilbert's LLP
- Agent Matthew D. Powell
- International Application: PCT/CA2012/050483 WO 20120712
- International Announcement: WO2013/006978 WO 20130117
- Main IPC: A61K38/45
- IPC: A61K38/45 ; C07K19/00 ; C12N9/10 ; A61K47/48 ; A61K38/00
Abstract:
Isolated polypeptides are disclosed herein, the isolated polypeptides comprising at least 90% identity to any one of: SEQ ID NO:1; SEQ ID NO:2; or SEQ ID NO:3, wherein the isolated polypeptide inhibits an interaction between palmitoyl acyl transferase zinc-finger DHHC type containing 17 (z D17) and c-jun N-terminal kinase (JNK). The polypeptides may be conjugated to a delivery and targeting moiety, such as the cell-membrane transduction domain of the HIV-1 Tat protein. There are also provided methods for treating a disease associated with cytotoxicity or excitotoxicity.
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