Invention Grant
- Patent Title: Modified gram positive bacteria and uses thereof
- Patent Title (中): 改良革兰氏阳性菌及其用途
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Application No.: US14346504Application Date: 2012-09-21
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Publication No.: US09458467B2Publication Date: 2016-10-04
- Inventor: Lothar Steidler , Karolien Van Huynegem , Klaas Vandenbroucke
- Applicant: INTREXON ACTOBIOTICS NV
- Applicant Address: BE Zwijnaarde
- Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee Address: BE Zwijnaarde
- Agency: Drinker Biddle & Reath LLP
- Priority: EP11182642 20110923
- International Application: PCT/EP2012/068633 WO 20120921
- International Announcement: WO2013/041672 WO 20130328
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A01N63/02 ; A01N63/00 ; C12N1/20 ; C12N1/00 ; C12N15/74 ; C12N1/04 ; C12N9/10 ; A23L1/30 ; A61K38/00 ; A61K39/00 ; C07K14/325 ; C12N15/86 ; A61K35/744
Abstract:
The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
Public/Granted literature
- US20140234371A1 MODIFIED GRAM POSITIVE BACTERIA AND USES THEREOF Public/Granted day:2014-08-21
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