Invention Grant
US09458505B2 Diagnosis of cowden and cowden-like syndrome by detection of decreased killin expression
有权
通过检测降低的杀伤细胞表达来诊断乳头和类牛综合征
- Patent Title: Diagnosis of cowden and cowden-like syndrome by detection of decreased killin expression
- Patent Title (中): 通过检测降低的杀伤细胞表达来诊断乳头和类牛综合征
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Application No.: US13721696Application Date: 2012-12-20
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Publication No.: US09458505B2Publication Date: 2016-10-04
- Inventor: Charis Eng
- Applicant: Charis Eng
- Applicant Address: US OH Cleveland
- Assignee: The Cleveland Clinic Foundation
- Current Assignee: The Cleveland Clinic Foundation
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04
Abstract:
A method of diagnosing Cowden syndrome (CS) and Cowden-like Syndrome (CLS) is described. The method includes diagnosing CS and CLS in a subject by identifying a decrease in expression of the KILLIN gene, or by identifying hypermethylation of the KILLIN promoter region. Kits for diagnosing CS and CLS by identifying subjects having KILLIN promoter region hypermethylation and primers specific for a methylated KILLIN promoter region are also described.
Public/Granted literature
- US20130157958A1 DIAGNOSIS OF COWDEN AND COWDEN-LIKE SYNDROME BY DETECTION OF DECREASED KILLIN EXPRESSION Public/Granted day:2013-06-20
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