Invention Grant
US09458515B2 RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound
有权
包括核苷化合物的RNA,用于调节由RNA产生的蛋白质的量的方法和核苷化合物
- Patent Title: RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound
- Patent Title (中): 包括核苷化合物的RNA,用于调节由RNA产生的蛋白质的量的方法和核苷化合物
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Application No.: US13582674Application Date: 2011-02-18
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Publication No.: US09458515B2Publication Date: 2016-10-04
- Inventor: Shinji Ogasawara , Mizuo Maeda
- Applicant: Shinji Ogasawara , Mizuo Maeda
- Applicant Address: JP Wako-shi, Saitama
- Assignee: RIKEN
- Current Assignee: RIKEN
- Current Assignee Address: JP Wako-shi, Saitama
- Agency: Casmir Jones, SC
- Priority: JP2010-055135 20100311
- International Application: PCT/JP2011/053577 WO 20110218
- International Announcement: WO2011/111501 WO 20110915
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12Q1/68 ; C07H19/20 ; C07H19/167 ; C07H19/173 ; C07H21/02

Abstract:
An RNA of the present invention is an RNA containing a 5′ cap structure and a coding region having a 5′ initiation codon and a 3′ stop codon on both ends of the coding region, the RNA having a nucleoside compound introduced at a site selected from among the 5′ cap structure and 10 bases from a 5′ end of the RNA, wherein the nucleoside compound is such that a group is attached to (i) a carbon atom at position 8 of a purine nucleus or (ii) a carbon atom at position 5 or 6 of a pyrimidine nucleus, the group being represented by formula (I): A-X═X-# (I) where A represents an aryl group or a heteroaryl group, # represents a site where the group represented by the formula (I) is attached to the carbon atom at the position 8 of the purine nucleus or the carbon atom at the position 5 or 6 of the pyrimidine nucleus, and two Xs, which are identical to or different from each other, each represents a nitrogen atom or CH whose H may be substituted by alkyl.
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