Invention Grant
US09458515B2 RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound 有权
包括核苷化合物的RNA,用于调节由RNA产生的蛋白质的量的方法和核苷化合物

  • Patent Title: RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound
  • Patent Title (中): 包括核苷化合物的RNA,用于调节由RNA产生的蛋白质的量的方法和核苷化合物
  • Application No.: US13582674
    Application Date: 2011-02-18
  • Publication No.: US09458515B2
    Publication Date: 2016-10-04
  • Inventor: Shinji OgasawaraMizuo Maeda
  • Applicant: Shinji OgasawaraMizuo Maeda
  • Applicant Address: JP Wako-shi, Saitama
  • Assignee: RIKEN
  • Current Assignee: RIKEN
  • Current Assignee Address: JP Wako-shi, Saitama
  • Agency: Casmir Jones, SC
  • Priority: JP2010-055135 20100311
  • International Application: PCT/JP2011/053577 WO 20110218
  • International Announcement: WO2011/111501 WO 20110915
  • Main IPC: C12N15/11
  • IPC: C12N15/11 C12Q1/68 C07H19/20 C07H19/167 C07H19/173 C07H21/02
RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound
Abstract:
An RNA of the present invention is an RNA containing a 5′ cap structure and a coding region having a 5′ initiation codon and a 3′ stop codon on both ends of the coding region, the RNA having a nucleoside compound introduced at a site selected from among the 5′ cap structure and 10 bases from a 5′ end of the RNA, wherein the nucleoside compound is such that a group is attached to (i) a carbon atom at position 8 of a purine nucleus or (ii) a carbon atom at position 5 or 6 of a pyrimidine nucleus, the group being represented by formula (I): A-X═X-#  (I) where A represents an aryl group or a heteroaryl group, # represents a site where the group represented by the formula (I) is attached to the carbon atom at the position 8 of the purine nucleus or the carbon atom at the position 5 or 6 of the pyrimidine nucleus, and two Xs, which are identical to or different from each other, each represents a nitrogen atom or CH whose H may be substituted by alkyl.
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