A bipolar ESD protection device includes a substrate having a p-type epi layer thereon including an epi region over an n-buried layer (NBL). An n-type isolation tank (iso tank) includes a deep n+ region and NBL for containing an isolated epi region of the epi region. An NPN transistor and an avalanche diode are formed in the isolated epi region. The NPN transistor includes an emitter within a base having a base contact and the collector is a top portion of NBL. The avalanche diode includes a p-type anode region including an anode contact and an n-type cathode region having a cathode contact. The anode region and base are resistively coupled through the epi region. A ground connection couples the emitter to the anode contact and a strike node connection couples the cathode contact to an n+ isolation contact.