In one embodiment, a circuit comprises a power amplifier. The circuit further comprises a memory that stores bias current values corresponding to a plurality of frequencies across a frequency band for setting the bias of a power amplifier based on selected frequencies, and a controller configured to provide at least one bias current value corresponding to a selected frequency from the memory to the power amplifier in response to a frequency selection signal. The bias current value at each frequency may be selected to maximize power efficiency or minimize adjacent channel leakage-power ratio of the power amplifier at said frequency. In one embodiment, the memory further stores bias current values corresponding to the plurality of frequencies across the frequency band at a plurality of temperatures for setting the bias of a power amplifier based on a temperature of the power amplifier and on selected frequencies.