Provided are a method and a system for filtering out adjacent frequency band interference. The method includes that an RF MEMS switch control module receives a first transmitted coupling signal from a first frequency band RF module and a second received coupling signal from a second frequency band RF module; the RF MEMS switch control module determines whether interference exists between a first frequency band and a second frequency band according to the first transmitted coupling signal and the second received coupling signal; if interference exists, the RF MEMS switch control module filters out the interference by instructing a first frequency band RF MEMS radio frequency reconfigurable antenna working in the first frequency band to change a first antenna structure and/or by instructing a second frequency band RF MEMS radio frequency reconfigurable antenna working in the second frequency band to change a second antenna structure. By means of the disclosure, adjacent frequency bands can co-exist on hardware and mutual interference is effectively avoided.