A method and system for wireless communication in a wireless communication network. The wireless communication network has a first mobile terminal and a second mobile terminal arranged in virtual multiple input, multiple output (“V-MIMO”) communication with a base station. A first wireless communication uplink channel corresponding to the first mobile terminal is estimated. The estimate is based on a first reference symbol signal and the cancellation of interference from a second reference symbol signal received from the second mobile terminal. A second wireless communication uplink channel corresponding to the second mobile terminal is estimated. The estimate is based on the second reference symbol signal and the cancellation of interference from the first reference symbol signal received from the first mobile terminal. The estimated first wireless communication uplink channel is used to demodulate a first data signal received from the first wireless device, and the estimated second wireless communication uplink channel is used to demodulate a second data signal received from the second wireless device.