Disclosed is a method for establishing an X2 interface IPSec tunnel. The method comprises: obtaining, by using SI signaling, IP information of a peer end base station for establishing an inter-base station X2 interface coupling link; automatically generating or receiving configuration data automatically generated and delivered by an operation and maintenance center and used for establishing the inter-base station X2 interface coupling link and configuration data used for establishing an inter-base station X2 interface IPSec tunnel; generating an X2 interface coupling packet according to the configuration data used for establishing the inter-base station X2 interface coupling link; and generating an IPSec negotiation packet according to the configuration data used for establishing the inter-base station X2 interface IPSec tunnel, and triggering the establishment of the inter-base station X2 interface IPSec tunnel by using the X2 interface coupling packet. Also disclosed are a base station, a system and a computer storage medium.